THE CONTRIBUTION OF MOSAIC VARIANTS TO AUTISM SPECTRUM DISORDER.

The Contribution of Mosaic Variants to Autism Spectrum Disorder.

De novo mutation is highly implicated in autism spectrum disorder (ASD).However, the contribution of post-zygotic mutation Dab Rig to ASD is poorly characterized.We performed both exome sequencing of paired samples and analysis of de novo variants from whole-exome sequencing of 2,388 families.While we find little evidence for tissue-specific mosaic

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Wnt Signalling in Regenerative Dentistry

Teeth are complex structures where a soft dental Chocolate Machines pulp tissue is enriched with nerves, vasculature and connective tissue and encased by the cushioning effect of dentin and the protection of a hard enamel in the crown and cementum in the root.Injuries such as trauma or caries can jeopardise these layers of protection and result in

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Clearing the JUNQ: the molecular machinery for sequestration, localization, and degradation of the JUNQ compartment

Cellular protein homeostasis (proteostasis) plays an essential role in regulating the folding, sequestration, and turnover of misfolded proteins via a network of chaperones and clearance factors.Previous work has shown that misfolded proteins are spatially sequestered into membrane-less compartments in the cell as part of the proteostasis process.S

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Optimization of the biodecolorization activity of the Ayapers dye removal by Halmonas sp. isolated from Urmia Lake

Background: Among chemical dyes, Azo dyes, as environmental synthetic pollutants, are most commonly used in a bunch of different colors in different industries, especially in textile industry to a large extent.Methods: Due to some limitation and difficulties to remove these pollutants from the environment, the biological filtering method, as the ec

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